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Journal: Journal of Radiation Research and Applied Sciences
Article Title: Ondansetron and AS19 attenuate morphine tolerance by modulating serotonin 5-HT3 and 5-HT7 receptor expressions in rat dorsal root ganglia
doi: 10.1016/j.jrras.2023.100682
Figure Lengend Snippet: Fig. 6. Effects of drugs on 5-HT7 receptor expressions in dorsal root ganglia. (A) image shows 5-HT7 receptor expressions immunohistochemically in DRG sections (magnification, ×400). (B) image shows the H-score means of 5-HT7 receptor expressions (n = 6). *p < 0.01 vs. saline treated group, **p < 0.05 vs. morphine- tolerant group, #p < 0.05 vs. morphine-tolerant group. MOR, morphine; MOR TOL, morphine tolerant; SB; SB-269970; SAL, saline.
Article Snippet: Then, rabbit polyclonal 5-HT3A (5 μg/ml; Abcam Biotech, Cambridge, UK) and
Techniques: Saline
Journal: Journal of Radiation Research and Applied Sciences
Article Title: Ondansetron and AS19 attenuate morphine tolerance by modulating serotonin 5-HT3 and 5-HT7 receptor expressions in rat dorsal root ganglia
doi: 10.1016/j.jrras.2023.100682
Figure Lengend Snippet: Fig. 7. Possible mechanism for ondansetron and AS19 to attenuate morphine anticiceptive tolerance. Ondansetron inhibits 5-HT3 receptor upregulation in the DRG and AS19 prevents 5-HT7 receptor downregulation. Both effects reduce morphine anticiceptive tolerance. DRG, dorsal root ganglion.
Article Snippet: Then, rabbit polyclonal 5-HT3A (5 μg/ml; Abcam Biotech, Cambridge, UK) and
Techniques: